Abstract: Apical surgery serves as the primary salvage treatment for persistent periapical lesions following failed root canal therapy (RCT). Over the past decade, this field has undergone a paradigm shift from "blind resection" to "precision intervention" driven by the integration of digital imaging, minimally invasive techniques, bioactive materials, and regenerative strategies. This systematic review summarizes the latest advances in apical surgery, focusing on digital navigation systems, minimally invasive resection technologies, novel retrograde filling materials, and periapical tissue regeneration approaches. We also analyze current clinical challenges and future development directions to provide evidence-based references for endodontic practice. A comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library using keywords including "apical surgery", "endodontic microsurgery", "digital navigation in endodontics", and "periapical regeneration". Relevant studies published between 2018 and 2025 were included, and the final analysis covered 40 high-quality articles (randomized controlled trials, systematic reviews, and prospective cohort studies). Read More

Abstract: Opioids, as frontline analgesics, are associated with substantial adverse effects. For example, μ-opioid receptor agonists commonly cause respiratory depression and carry high addictive potential, while κ-opioid receptor agonists can produce depression-like reactions and aversion. The introduction of biased agonism has offered a strategy to dissociate opioid-induced adverse effects from analgesic efficacy. In recent years, biased agonists developed for different opioid receptor types have shown promise in reducing side effects, lowering addictive liability, and achieving analgesia with improved therapeutic windows, suggesting the possibility of a safer next generation of analgesics. However, important obstacles and challenges remain. Read More

Abstract: This systematic review and meta-analysis evaluates the effects of progressive resistance training (PRT) on muscle mass, muscle strength, and physical function in elderly patients with sarcopenia. Eleven randomized controlled trials involving 316 participants were included. The results indicate that PRT significantly improves grip strength (SMD = 3.22, 95% CI: 2.62–3.82, P < 0.00001), gait speed (SMD = 0.51, 95% CI: 0.27–0.75, P < 0.00001), and skeletal muscle index (SMD = 0.39, 95% CI: 0.07–0.72, P = 0.02). However, PRT did not show significant effects on chair stand time or the Short Physical Performance Battery (SPPB) score. The findings suggest that PRT is a feasible and effective intervention for improving certain aspects of sarcopenia in the elderly, though its impact on comprehensive physical function requires further investigation. Read More

Abstract: The digital economy has become a core driving force in reshaping industrial forms and regional competitiveness. The deep integration of "sports + tourism," as a vital path to meeting the people's needs for a better life, is facing a critical moment of digital transformation. However, traditional industrial policy tools and governance mechanisms exhibit significant "failure" and "mismatch" when addressing the new characteristics brought by the digital economy, such as rapid iteration, cross-border integration, and data-driven approaches. This paper, focusing on Qingyuan City—an ecological barrier and leisure tourism destination in the Guangdong-Hong Kong-Macao Greater Bay Area—addresses the practical policy challenges faced by its integrated "sports + tourism" development. Utilizing policy tool theory and collaborative governance theory, this paper first analyzes the empowering logic of the digital economy on "sports + tourism" integration. It then diagnoses the core dilemmas in Qingyuan, including the imbalanced supply of policy tools, the "fragmentation" of departmental collaboration, and the "time-lag" in policy execution. Building on this, the paper systematically constructs an innovative policy toolbox adapted to the digital economy from four dimensions: environmental, supply-side, demand-side, and governance. Furthermore, it designs a "five-in-one" policy collaborative governance mechanism covering target, organizational, resource, process, and information collaboration. This research aims to provide a policy framework and governance plan that is both theoretically forward-looking and practically operable for Qingyuan and similarly-situated cities to promote the high-quality development of the "sports + tourism" industry in the digital age. Read More

Abstract: Root canal therapy (RCT) serves as the cornerstone treatment for irreversible pulpitis, pulp necrosis, and periapical lesions. With the integration of digital technology, biomaterials science, and artificial intelligence (AI), the paradigm of RCT has shifted from "infection elimination" to "functional reconstruction" and "tissue regeneration". This systematic review summarizes the latest advances in RCT, focusing on digital diagnostic tools, intelligent treatment systems, novel biomaterials, and regenerative endodontic strategies. We also discuss the current challenges and future directions, aiming to provide a comprehensive reference for clinical practice and scientific research. A literature search was conducted in PubMed, Embase, and Cochrane Library databases using keywords such as "root canal therapy", "digital endodontics", "regenerative endodontics", and "artificial intelligence in dentistry". Relevant studies published between 2018 and 2025 were included, and the final analysis covered 40 high-quality articles (randomized controlled trials, systematic reviews, and prospective cohort studies). Read More

Abstract: The formation and development of new quality productive forces depend not only on technological breakthroughs but also on high-quality application-oriented talents who master new knowledge, new technologies, and new processes. As the intersection of the Northern Guangdong Ecological Development Area and the undertaking ground for industrial transfer from the Pearl River Delta, Qingyuan City faces dual challenges in the process of promoting the digital, intelligent, and green transformation and upgrading of its manufacturing industry: a structural shortage of application-oriented talent supply and the poor operation of the "Government-Industry-University-Research" collaborative mechanism. Based on the connotation and characteristics of new quality productive forces, this paper analyzes the new requirements for the quality of application-oriented talents. It examines the realistic dilemmas in the current local "Government-Industry-University-Research" collaborative training mode, such as "divergent government guidance, involution of enterprise participation, lagging adaptability of universities, and inefficient conversion rate of scientific research." Based on the "Quadruple Helix" innovation theory and collaborative governance theory, this paper constructs a new "Government-Industry-University-Research" collaborative mode centered on the deep integration of the "industrial chain, innovation chain, education chain, and talent chain." Combined with the construction of the "Provincial Vocational Education City" in Qingyuan and the practice of the "Hundreds, Thousands, and Ten Thousands Project," specific innovation paths are proposed, such as co-constructing modern industrial colleges, creating regional industry-education consortia, and building a full-life-cycle talent service ecosystem. The aim is to provide theoretical support and a practical paradigm for underdeveloped areas to drive the development of new quality productive forces relying on the talent engine. Read More

Abstract: Objective: To investigate the health effects of radiation exposure among medical radiation diagnostics practitioners. Methods: A total of 1125 medical radiation diagnostics workers who underwent occupational health examinations between 2023 and 2024 were selected as the study subjects. They were categorized into groups based on gender, age, and length of service. Differences in white blood cell count, platelet count, and chromosomal aberration rates among the groups were analyzed. Logistic regression was used to identify factors influencing the rate of chromosomal aberrations. Results: Among the 1125 workers, 684 (60.8%) were male and 441 (39.2%) were female. The non-aberration group comprised 1060 individuals (94.2%), with a mean radiation exposure duration of 6.85 ± 8.137 years and a mean age of (33.17 ± 10.420) years. The chromosomal aberration group included 65 individuals (5.8%). Radiation exposure time and age were identified as influencing factors for chromosomal aberrations in radiation workers (P < 0.05). For each additional year of radiation exposure, the risk of chromosomal aberrations increased by 3.9% (OR = 1.039, 95% C.I. 1.013-1.067). Conclusion: Long-term, low-dose ionizing radiation exposure leads to an increased incidence of chromosomal aberrations. Enhanced monitoring and improved radiation protection for medical radiation practitioners are recommended. Read More

Abstract: Periodontal surgery is the core treatment for moderate to severe periodontitis, aiming to control infection, eliminate periodontal pockets, and restore periodontal tissue function. Over the past decade, driven by the integration of digital medicine, tissue engineering, and minimally invasive technology, periodontal surgery has achieved a paradigm shift from "disease control" to "functional regeneration". This systematic review summarizes the latest progress in periodontal surgery, focusing on digital diagnosis and navigation, minimally invasive debridement techniques, periodontal regenerative therapy, and aesthetic periodontal surgery. We also analyze current clinical challenges and future development directions to provide evidence-based support for periodontal clinical practice. A comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library using keywords including "periodontal surgery", "minimally invasive periodontal therapy", "periodontal regeneration", and "digital periodontology". Relevant studies published between 2018 and 2025 were included, and the final analysis covered 40 high-quality articles (randomized controlled trials, systematic reviews, and prospective cohort studies). Read More