Abstract: Objective: To investigate the exercise benefits/barriers and influencing factors among cardiovascular disease (CVD) patients seeking emergency care. Methods: A convenience sampling method was used to select CVD patients who visited the emergency department of a tertiary hospital in Chengdu from December 2023 to July 2024 as the study subjects. The investigation was conducted through medical record review and on-site questionnaire surveys. The research tools included a general information questionnaire, the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the Exercise Benefits/Barriers Scale (EBBS), the Exercise Self-Efficacy Scale, the Patient Health Questionnaire-9 (PHQ-9), and the Social Support Rating Scale (SSRS). Data were entered into Excel and statistically analyzed using SPSS 26.0. Results: Among the 1080 patients, 62.9% did not meet physical activity standards. Depression and social support explained 48.0% of the total variance in exercise benefits/barriers. The random forest algorithm performed best in predicting influencing factors. Conclusion: CVD patients seeking emergency care are generally insufficiently active, with depression and social support significantly impacting exercise benefits/barriers. Read More

Abstract: Baduanjin, a traditional Chinese health care practice, not only promotes muscle relaxation and bone strengthening while preventing and treating illnesses but also contributes positively to mental nourishment and emotional regulation. This paper employs a literature review and logical analysis to comprehensively assess the impact of Baduanjin on the mental health of medical students in higher education institutions. The findings indicate a significant prevalence of mental health issues among medical students in recent years, with a myriad of complex influencing factors. Furthermore, interventions aimed at enhancing the mental well-being of college students have become increasingly diverse. Notably, Baduanjin stands out as a traditional physical activity intervention that is both straightforward to implement and effective in bolstering students' mental health. Moving forward, it may serve as a preventive measure for mental wellness in the physical education curricula of universities, fostering the holistic development of both physical and mental health. Read More

Abstract: Vaccines, as an essential means of preventive medicine, profoundly impact human health by stimulating an immune response to protect the body from pathogens or treat diseases. However, conventional vaccine delivery methods have limitations such as multiple injections, rapid degradation in vivo, and difficulty in targeted delivery. The development of controlled release mechanisms has overcome these challenges, optimized the immune response and improved the efficacy and safety of vaccines by precisely controlling the time, space and dose of vaccine release in vivo. This review explores the fundamentals, recent applications and future directions of controlled release mechanisms in vaccine delivery, focusing on the design and application of intelligent delivery systems such as biodegradable nanoparticles, self-healing microspheres, scaffolded vaccines and targeted vaccine systems. With the continuous progress of biotechnology and nanotechnology, controlled-release vaccines herald a new direction in vaccine design and delivery and bring efficient vaccine products to global public health. Read More

Abstract: Objective: This study evaluates the impact of the Enhanced Recovery After Surgery (ERAS) program on postoperative outcomes in patients undergoing pancreatic cancer surgery. It compares traditional perioperative care with ERAS-based interventions, focusing on key rehabilitation indicators such as postoperative intestinal function recovery, length of hospital stays, medical costs, and the incidence of complications. Methods: A total of 74 patients were studied, with 37 receiving traditional perioperative care and 37 managed under the ERAS protocol. Data collection included intraoperative indicators such as operation time, fluid input, blood loss, and postoperative recovery measures like first ambulation, pain scores, and complications. Results: The ERAS group demonstrated significantly faster recovery of gastrointestinal function, earlier mobilization, and reduced postoperative pain within the first 12 hours compared to the control group (p<0.05). The incidence of postoperative complications was lower in the ERAS group (13.51% vs. 37.84%, p=0.0166). Furthermore, the ERAS protocol led to a shorter length of hospital stay and lower total medical costs (p<0.0001). Conclusion: The implementation of the ERAS protocol for pancreatic cancer surgery significantly improves recovery outcomes, reduces complications, and lowers healthcare costs. These findings support the broader adoption of ERAS protocols in pancreatic cancer management to optimize clinical and economic outcomes. Read More

Abstract: This study used colloidal gold immunoassay strips and PCR (probe method) kit methods to detect Salmonella and Listeria monocytogenes. The accuracy and precision of the colloidal gold immunoassay strips and PCR (probe method) kit methods were validated using proficiency testing blind samples, and the consistency with the current national gold standard method was compared. The results of the two rapid detection methods were consistent with the results of the national standard method. This paper also analyzed the detection time and cost of the two rapid detection methods and the national standard method. The PCR (probe method) kit method takes less time for detection and can be used for high-throughput detection, with high sensitivity and low interference. It requires high equipment and personnel capabilities. The colloidal gold immunoassay strips method has the lowest detection cost, but its sensitivity is lower than that of the PCR method. It is easy to operate and requires low personnel and equipment requirements. Laboratories can choose the appropriate method based on their actual needs. Read More

Abstract: Photobiomodulation (PBM), a therapeutic modality utilizing low-intensity light in the visible and near-infrared spectrums, has garnered significant attention in the field of dentistry, particularly in the context of orthodontic treatment. This study delves into the mechanisms by which PBM influences tooth movement, examines its efficacy in accelerating orthodontic procedures, and discusses potential clinical implications. By analyzing recent advancements and research findings, we aim to provide an in-depth understanding of PBM&#39; s role in enhancing patient outcomes and treatment experiences. Read More

Abstract: This study evaluates the effectiveness of a mindfulness-based nursing intervention in enhancing mindfulness, self-management efficacy, and quality of life in breast cancer patients. Using a randomized controlled trial design, 80 participants were divided into intervention (n=40) and control (n=40) groups. The intervention group participated in an 8-week mindfulness program, while the control group received standard care. Results demonstrated significant improvements in mindfulness, self-management efficacy, and quality of life in the intervention group. This suggests that mindfulness training could serve as a valuable supportive therapy for promoting psychological well-being in breast cancer patients. Read More

Abstract: This study explores the perceptions and experiences of Chinese registered nurses regarding the clinical use of alternative medicine. The research focuses on nurses from various departments and roles, including specialist nurses, clinical nurses, and nursing management personnel. Through interviews, participants share their experiences, challenges, and views on alternative medicine in their daily work. The data collected will be analyzed using the Collaizi method. The study identifies four main themes: the development of alternative medicine in China, the challenges faced by nurses, how they overcome these challenges, and their predictions for the future of alternative medicine in the country. Key findings highlight the emotional impact of work changes, the difficulties encountered in the nursing profession, and nurses’ resilience. Lastly, participants offer insights into the future of alternative medical practices in China. Read More

Abstract: Oral bacterial diseases include caries, periodontal disease, gingivitis, and oral cancer, and they are usually associated with an imbalance in the regulation of the oral microbiota. In the prevention and treatment of oral bacterial diseases, in addition to good oral hygiene habits and traditional treatments, studies have shown that a variety of emerging technologies, such as gingival mesenchymal stem cells (GMSCs), novel nanomaterial-based antibacterial photodynamic therapies, fluorescence molecular imaging, programmed death receptor ligand-1 positron emission tomography (PD-L1 PET), and so on, have shown high efficacy in the treatment of oral and bacterial diseases. Bacterial diseases have demonstrated high efficiency, safety, and personalized therapeutic effects. However, there are limitations such as the lack of large-scale clinical trials for many of these technologies. Read More

Abstract: This study aims to evaluate the efficacy and safety of warming acupuncture combined with the Ziwu Liuzhu method in D-IBS treatment and to investigate its potential mechanisms, including regulating gastrointestinal motility, neuro-immune networks, and gut microbiota balance. Methods: A randomized controlled trial was conducted with D-IBS patients who met diagnostic criteria, divided into three groups: warming acupuncture group, combined Ziwu Liuzhu and warming acupuncture group, and control group. The warming acupuncture group received warm needle stimulation at specific acupoints, while the combined group received treatments at specific times on Spleen and Stomach meridians according to the Ziwu Liuzhu method. Treatment outcomes were assessed using IBS symptom severity scores, quality of life scores, inflammatory marker analysis, and gut microbiota profiling. Results: The combined Ziwu Liuzhu and warming acupuncture group showed significant improvement in relieving diarrhea, abdominal pain, and bloating, with longer-lasting effects. This group also exhibited superior enhancement in gastrointestinal motility, neuro-immune function, and gut microbiota balance compared to the other groups. Additionally, the combined therapy demonstrated good safety, with no significant adverse effects observed. Read More

Abstract: Objective: This study aims to explore the regulatory effects and potential mechanisms of Junfang tea extract on metabolic disorders induced by a high-sugar, high-fat diet. Methods: A high-sugar, high-fat mouse model was established, and 220 healthy male mice were randomly divided into seven groups: normal control group (NC), model control group (MC), positive control group (PC), and four Junfang tea extract groups (DYA, DYB, DYC, DYD). The NC and PC groups consisted of 35 mice each, while the other groups had 30 mice each. The NC group was fed a standard diet, while the other groups were fed a high-sugar, high-fat diet for 8 weeks to induce the model. Starting from the 9th week, the observation groups were administered different doses of Junfang tea extract by gavage, while the PC group received metformin and lovastatin as positive controls. In the 15th week, blood samples were collected, and serum was separated for the measurement of glucose (Glu), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB), urea, and creatinine levels. Results: Tea polyphenols and catechins are the main active components in Junfang tea, which regulate several metabolic pathways, including fatty acid oxidation, fat synthesis, and glucose metabolism, by modulating the AMPK, PPAR, and SREBP signaling pathways. Differential metabolite analysis showed that the abundance of Sinapoylhexoside and other metabolites was significantly higher in the NC group than in the MC group, suggesting its potential role in maintaining metabolic balance. Pathway Impact analysis revealed that Junfang tea significantly alleviated metabolic disorders induced by a high-sugar, high-fat diet through the regulation of key signaling pathways, such as AKT, mTOR, NF-κB, and JNK. Multi-group comparison analysis indicated that the metabolic state of group D showed noticeable improvement, … Read More

Abstract: Globally, non-small cell lung cancer (NSCLC) is the primary cause of death from cancer. Immunotherapy has advanced significantly in the medical management of NSCLC over the previous couple of decades. Particularly immune checkpoint drugs that target programmed death receptor 1 (PD-1) and its ligand 1 (PD-L1). Meanwhile, miRNAs are crucial for controlling the PD-1/PD-L1 pathway in NSCLC and are an increasingly significant field of investigation at the moment. For these reasons, this paper reviewed the mechanism of the PD-1/PD-L1 pathway in immunological escape from malignant cells and explored how non-coding RNAs (including microRNAs, long-chain non-coding RNAs, and cyclic RNAs) can affect the occurrence as well as growth of NSCLC by regulating PD-1/PD-L1 activity. Argument cites specific miRNAs such as miRNA-200c have the capability to alter the level of PD-L1 expression and thus enhance cancer innate immunity. Beyond that, LncRNA such as NEAT1 affect expression of PD-L1 and evasion of the body's defenses through interaction with miRNAs. In NSCLC, circular RNAs are performing a crucial function in evading immune responses. The article also discusses the efficacy and challenges of our self-developed PD-1 inhibitors in treating advanced NSCLC and emphasizes the need to improve the precision of immunotherapy. Finally, the article highlights the necessity for additional investigation to uncover more upstream modulators to enhance the prognosis and clinical outcomes of NSCLC individuals. Read More

Abstract: This study summarizes the nursing experience of dental implant restoration in a patient with cerebral palsy and dentition defect. We applied the PDCA nursing mode throughout the patient's treatment process and observed significant positive outcomes. The surgery and nursing care proceeded smoothly, with the patient's neurological functions remaining stable postoperatively. The dental implant showed good osseointegration, healthy surrounding soft tissues, and no signs of bone loss in radiographic examinations. The patient's oral hygiene remained consistent. This case highlights the effectiveness of the PDCA nursing mode in improving nursing quality, promoting patient recovery, and reducing complications in patients with dentition defects and cerebral palsy undergoing dental implant surgery. This approach holds significant clinical implications and merits wider adoption. Read More

Abstract: Passive acoustic monitoring (PAM) technology can obtain the sound information of aquatic organisms without causing disturbance or damage to aquatic organisms, and use the information for various ecological research and aquaculture activities management. With the continuous improvement and progress of prawn culture technology, the density of prawn culture continues to increase, but the problems such as low feed utilization rate and deteriorating water quality seriously restrict the rapid development of prawn culture. The use of passive acoustic monitoring technology can realize intelligent automatic feeding, improve feed utilization and alleviate water quality deterioration. This paper mainly describes the feeding process of prawn and its influencing factors, summarizes the research progress and application of passive acoustic monitoring technology in the acoustic signal of prawn feeding in recent years, analyzes the advantages and disadvantages of passive acoustic monitoring technology, and puts forward the future development trend in view of the existing problems, in order to provide a reference for the automatic feeding system to become intelligent. Read More

Abstract: Zhu Danxi's emotional disorder theory, as an important part of traditional Chinese medicine, reveals the etiology and treatment methods of emotional disorders through core concepts such as the "Theory of Qi, Blood, Phlegm, and Stagnation," and the "Theory of Ministerial Fire." This paper explores the application of Zhu Danxi’s theories, such as the Yin-Nourishing Theory, Six Stagnations Theory, and Emotion Regulating Method, in comparison with modern emotional disorder therapies such as cognitive therapy and Morita therapy. Research shows that Zhu's theory not only has unique advantages in regulating emotions and balancing the mind and body but also provides innovative ideas for modern mental disorder treatment, emphasizing dialectical treatment and emotional regulation. On this basis, the paper proposes combining Zhu Danxi's theories with modern treatment methods to create a more personalized and comprehensive emotional disorder treatment system to improve clinical efficacy and patient quality of life. This paper aims to promote the integration of traditional Chinese emotional disorder theories with modern psychology and provide new theoretical foundations and practical guidance for Chinese medicine psychology. Read More

Abstract: Background: Traumatic brain injury (TBI) affects 280-1373/100,000 young people globally each year, with non-traumatic acquired brain injury (ABI) affecting an additional 82.3/100,000 [1]. ABI leads to long-term negative impacts on patients, families, and society, costing the global economy around US$400 billion annually [2]. Objective: This study estimates the direct (hospitalisation) and indirect (opportunity costs from bed-days) costs of children with ABI. It also analyses factors influencing hospital length of stay, helping guide resource allocation. Methods: Using an incidence-based, bottom-up approach, average length of stay is used to estimate medical costs. Regression analyses (linear, logit, and ordered logit models) were used to assess factors influencing length of stay and ABI severity. Results: In 2020, 5667 new ABI cases in Queensland incurred $0.112 billion in total costs. The cost per mild case was $15,863.41, while severe cases averaged $300,049.61. Mild cases represented 75% of total costs. ICU stay length and ventilatory support duration were significant factors in cost analysis. Conclusion: Preventing secondary injury should be a priority in ABI care. Read More

Abstract: This study aims to analyze the temporal trends of blood-borne disease (hepatitis B, hepatitis C, HIV, and syphilis) screening results in Shiyan City, Hubei Province, from 2019 to 2023. The research is based on five years of monthly screening data from the Shiyan Central Blood Station, utilizing time series analysis methods including trend analysis, seasonal analysis, and ARIMA modeling. Results show that the screening positivity rates for hepatitis B and hepatitis C demonstrate a slow declining trend, while the positivity rates for HIV and syphilis remain relatively stable. All diseases exhibit significant seasonal fluctuations, with higher detection rates in summer. The study also finds that the COVID-19 pandemic in early 2020 had a significant impact on screening work, leading to a temporary decrease in testing volume. This research provides important evidence for understanding the prevalence trends of blood-borne diseases in Shiyan City, offering references for local blood safety management and public health decision-making, and potentially providing methodological insights for similar studies in cities of comparable scale. Read More

Abstract: The essay explores the relationship between Traditional Chinese Medicine (TCM) and the prevention and treatment of epidemics, emphasizing its historical roots and modern applications. It discusses how traditional Chinese cultural thought, including Confucianism and Daoism, influences public health ethics and preventative health approaches. The study highlights both the historical and contemporary roles of TCM in epidemic response, offering examples from classical texts and modern integration with public health practices. Additionally, the document analyzes the complementary strengths of TCM and modern medicine, such as TCM's holistic approach versus the precision of modern methods, and provides insights into future challenges and directions. Read More

Abstract: Objective To observe and study the efficacy of fascia knife technique combined with Italian fascia manipulation in patients with non-specific low back pain. Methods From May 2022 to November 2022, 40 interns and students with non-specific low back pain in Guangdong Industrial Injury Rehabilitation Hospital were selected as the study subjects. Randomized controlled experiment was used to divided them into control group and observation group, with 20 students in each group. The control group was treated with Italian fascia manipulation alone, and the experimental group was treated with fascia knife technique. After 4 weeks of treatment, the long-term course of treatment was evaluated comprehensively, and the pain score and the degree of dysfunction before and after treatment were compared between the two groups. Results After 4 weeks of treatment, the effective rate of observation group was 95.00% higher than that of control group (90.00%), but there was no significant difference between groups (x²=3.14, P > 0.05). Before and after treatment, there were significant differences in PRI sensory score, PRI emotional score, PRI total score, VAS and PPI scores between the two groups, which showed a decreasing trend, and the decrease rate of observation group was greater than that of control group (t=4.90, 3.68, 4.69, 3.40, 3.39, P < 0.05). The dysfunction scores of the two groups were significantly different before and after treatment, and showed a downward trend, and the dysfunction scores of the observation group after treatment were significantly lower than those of the control group (8.23±2.43) points (10.67±3.23) points (t=4.89, P < 0.05). Conclusion The combination of fascia knife technique and Italian fascia manipulation can achieve significant long-term results in patients with non-specific low back pain, alleviate pain symptoms and improve functional dysfunction. Read More

Abstract: This study explored the possibility of Aspergillus flavus contamination and toxin production during the fermentation of starter. Aspergillus flavus isolated from natural fermentation was selected as the research object, and mixed with Transocephalia racemosa and Mucor circinelloides to establish starter. Toxin production and toxin level of Aspergillus flavus in starter were analyzed by PCR, HPLC, competitive ELISAand mouse experiment. The results showed that the isolated Aspergillus flavus strain contained aflR, omt-1 and ver-1 gene fragments; HPLC chromatogram showed that this strain mainly produced AFB1 and the concentration was 16.8µg/kg; Aspergillus flavus grew well on the drug block under construction, completely covered the drug block surface after 36h, and had strong toxin production ability. When mixed with Transverse Rhizopus racemosus and Mucor circinellus to establish starter, the growth and toxin production ability of Aspergillus flavus were inhibited. Afteroral administration oftwo kinds of AFB1-containing extractsto mice, the liver tissue was obviously damaged, and Jianqu did not show inhibitory effect on the toxicity of AFB1. This study provides a reference for strengthening quality control and preventing pollution in the fermentation process of Jianqu. Read More