Abstract: Objective: To explore the relationship between personality traits and relapse tendency of drug addicts. Methods: 187 drug addicts were tested on the relapse tendency scale, and the results were analyzed by SPSS24.0. Results: (1) there is no difference in demographic variables in personality traits of drug users, and there is significant difference in the number of relapse tendencies entering drug rehabilitation centers; (2) there is a high correlation between personality traits and relapse tendency, in which there is significant negative correlation between inclination and relapse tendency, and stability and mental quality and relapse tendency. Conclusion: The close association between personality traits and the relapse tendency provides a new perspective for us to better understand the relapse tendency of drug users and their influencing factors. Read More

Abstract: Amidst the rapid advancement of medical technology, the role of gastrointestinal endoscopy in the early diagnosis of gastric cancer has become particularly crucial. This discourse elaborates upon the evolutionary journey of gastrointestinal endoscopy technology, ranging from the rudimentary functionalities and limitations of its primitive iterations to the integration of high-definition and digital capabilities. Emphasis is placed on discussing the contributions of these technological innovations to enhancing the precision of early gastric cancer detection. It delves into the advantages of different endoscopic techniques in observing the microstructures of gastric mucosa, underscoring the applicative value of high-definition endoscopy, chromoendoscopy, and optical magnification endoscopy in early gastric cancer diagnosis. Concluding remarks offer a glimpse into the future prospects of gastrointestinal endoscopy technology, underscoring the significance of continuous innovation. Read More

Abstract: This study explores the impact of food nutrition labels on consumer behavior through a cross-national survey and quantitative analysis. Globally, food nutrition labels have become an essential reference for consumers when choosing food products, and their significance is increasingly evident. Firstly, we found that the accuracy of food nutrition labels significantly influences consumer behavior. Accurate label information helps consumers make informed purchasing decisions, choosing healthier and more nutritious foods. However, inaccurate or misleading label information can lead to consumer misunderstanding, potentially triggering unhealthy eating habits or excessive intake of certain nutrients. Secondly, the readability and comprehensibility of food nutrition labels are also crucial factors affecting consumer behavior. Labels that are easy to read and understand provide more authentic and accurate product nutrition information, helping consumers quickly grasp the main ingredients and nutritional value of foods. Therefore, when designing food labels, manufacturers should focus on improving information readability and comprehensibility to facilitate consumer access to the required information. Furthermore, our research indicates that health claims and nutrition facts tables on food nutrition labels positively guide consumers' health awareness. An increasing number of consumers are beginning to pay attention to the nutritional content and health value of foods, preferring those labeled with health claims or nutrition facts tables. These labels not only provide scientific dietary advice to consumers but also help them control calorie intake and maintain healthy eating habits. In the cross-national survey, we also observed variations in consumer attention to food nutrition labels across different countries and regions. In developed countries, consumers tend to place a higher emphasis on food labels, whereas in developing countries, due to a lack of nutritional knowledge, … Read More

Abstract: Patella fractures are a common type of lower limb fractures, and their treatment strategies directly impact patients' recovery process and quality of life. In recent years, with the advancement of medical technology and the updating of rehabilitation concepts, optimizing treatment strategies for patella fractures has become a hot topic in clinical research. Based on a review of the current status of patella fracture treatment, this article focuses on several aspects of optimizing treatment strategies, including improving diagnostic accuracy, innovating treatment methods, improving postoperative rehabilitation training systems, and strengthening patient education and psychological support. Through in-depth analysis of specific measures and implementation paths in these areas, the article aims to provide more comprehensive, scientific, and effective guidance for the treatment of patella fractures, promoting early recovery of patients. Read More

Abstract: This paper delves into three pivotal themes concerning adenosine triphosphate (ATP): ATP cytotoxicity, ATP-induced cell death, and ATP depletion. Initially, we scrutinize ATP's involvement in cytotoxicity, with a specific focus on elucidating the mechanisms underlying cell demise triggered by augmented extracellular ATP concentrations. Subsequently, we investigate the process of ATP-induced cell death, emphasizing the repercussions of heightened extracellular ATP levels on cellular dynamics and associated biological responses. Lastly, we probe the impact of ATP depletion on cellular function and contemplate the plausible manifestation of cell death resulting from ATP depletion. Through a comprehensive examination of these topics, a deeper understanding of ATP's multifaceted role in cellular biology emerges, offering novel insights and strategies for the treatment and prevention of related diseases. Read More

Abstract: Lung cancer is the highest incidence of a disease and mortality in China. The incidence of a disease and mortality of lung cancer in China is among the highest in the world, and the probability of survivability is lower than other countries. However, there are still some practical issues in clinical practice, such as large toxic side effects of chemotherapeutic drugs, drug resistance, and fewer people who benefit from immunotherapy. Therefore, this paper aims to find a more safe, effective and reliable combination of drugs. In this paper, through reading, searching and screening a large number of basic and clinical studies, it is concluded that traditional Chinese medicine can not only play an anti-tumor effect through a variety of ways, but also prolong the survival period of patients with cancer and improve the quality of life of patients. In this paper, Astragalus membranaceus and Glycyrrhiza uralensis Fisch are selected as the legume of anti-lung cancer drugs. The effective components, pharmacological activity properties, anti-lung cancer mechanism and clinical application of treatment of lung cancer of Astragalus membranaceus and Glycyrrhiza uralensis Fisch are systematically combed in order to provide theoretical basis for the treatment and prevention of lung cancer. Read More

Abstract: With the rise of the aging population, the number of people with high blood pressure is increasing. Hypertension can cause cerebral hemorrhage, cerebral infarction, heart failure, coronary atherosclerotic heart disease and renal failure. One of the most common treatments for hypertension is drug therapy. Common anti-hypertensive drugs include angioplasty-converting enzyme inhibitors, calcium channel blockers, adrenergic receptor antagonists, diuretics, central anti-hypertensive drugs and vasodilation. The types of drugs used vary depending on the individual's condition. This article reviews the development history, classification, mechanism of action and rational application of the major anti-hypertensive drugs, so that more people can understand hypertension and provide more choices of drugs for hypertensive people. Read More

Abstract: This study aims to explore new metal drugs with different metal center-[Pt (4ʹ-(2-quin)-terpy) Cl] (SO3CF3), [Auʹ (4-(2-quin)-terpy) Cl] 2 • CH3CN (PF6), [Cu (4ʹ-(2-quin)-terpy) Cl] (PF6) in anticancer therapy and its mechanism of action. The three metal complexes were synthesized by chemical synthesis, and their structures were identified by means of NMR, mass spectrometry and single crystal X-ray diffraction. In vitro anticancer activity evaluation showed that these metal drugs showed different degrees of inhibitory effects on selected cancer cell lines, and the anticancer activity of [Pt (4ʹ-(2-quin)-Terpy)Cl] (SO3CF3) was the most significant. Further mechanism studies revealed that these metal drugs exert anti-cancer effects mainly through the interaction with DNA and inducing apoptosis of cancer cells. In addition, this study evaluated the toxicity of these drugs to normal cells, providing important safety information for their subsequent clinical use. The research in this paper not only enriches the understanding of anticancer mechanism of metal drugs, but also provides a valuable reference for the development of new, efficient and low-toxicity metal anticancer drugs. Read More

Abstract: This comprehensive paper takes a deep dive into the critical role played by drug-resistant oral microorganisms in the pathogenesis of periodontitis, along with the recent research advancements in this field. It begins by defining drug resistance and its underlying causes, delving into the various types of resistance encountered in oral microorganisms. The paper then shifts its focus to the complex pathogenesis of periodontitis, discussing how drug-resistant microorganisms contribute to the development and progression of this common oral disease. The intricate relationship between drug-resistant microorganisms and periodontitis is further explored, shedding light on how these microorganisms evade traditional antibiotic treatments and contribute to the persistence and recurrence of the disease. The paper also highlights the methodologies and cutting-edge techniques that researchers are utilizing to study this phenomenon, including advanced genomic sequencing, biofilm analysis, and animal models. The paper provides an overview of the latest research progress in this area, discussing promising new treatment strategies that are being developed to target drug-resistant microorganisms. These strategies include the use of novel antimicrobials, bacteriophage therapy, and immune-based approaches. Read More

Abstract: The immunologically mediated mechanisms within renal diseases represent a complex biological process. This study primarily focuses on analyzing the roles and mechanisms of immune cells, specifically macrophages, T cells, and B cells, in renal pathology. Utilizing a meticulous approach that combines bioinformatics analysis with in vitro experiments, this paper reveals the critical role of m6A RNA methylation modifications in regulating immune cell functions, promoting apoptosis, and inflammatory responses. The results suggest that the interactions among immune cells and their impact on renal health are of significant biological importance, and that the regulation of m6A methylation modifications presents new potential targets for renal disease treatment. However, as the study relies on in vitro experiment results, the findings necessitate further validation through additional animal experiments and clinical trials. Future research should delve deeper into the specific roles and interactions of different immune cells in various renal diseases to develop more effective treatment strategies. Read More

Abstract: Narrative medicine is an important part of medical education for trained doctors. This paper mainly discusses the application of narrative medicine teaching method in the teaching of medical students. Compared with traditional teaching methods, the results show that narrative medicine teaching method can significantly improve the clinical skills and doctor-patient communication skills of medical students, and the comprehensive evaluation of narrative medicine teaching method is higher. Therefore, the use of narrative medicine teaching method can effectively improve the teaching effect in internal medicine training medicine, which is a teaching method suitable for the development law of medical students and more valuable. Read More