Abstract: Retinoids are a group of compounds consisting of vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids can regulate the physiological functions of various organs and tissues and play an important role in normalising immune function, cell growth and differentiation. Vitamin A Vitamin A derivatives have a role in the treatment of tumours and ATRA has a role in the differentiation therapy of acute promyelocytic leukaemia (APL). ATRA and other retinoids also have many applications in dermatological conditions (e.g. skin cancer, psoriasis). ATRA and other retinoids also have many applications in dermatological conditions (e.g. skin cancer, psoriasis, acne and ichthyosis). In addition, the physiological functions of skin cells can also be regulated by modulating retinoic acid receptors and retinoid X (or rexinoid) receptors. The results of numerous genetic modelling experiments have shown that the regulation of retinoic acid receptors (RARs) and retinoid X (or rexinoid) receptors (RXRs) may have great potential for the treatment of serious skin diseases such as skin cancer. Here, we provide a synopsis of the main advances in understanding the role of ATRA and its receptors in dermatology. Read More

Abstract: To investigate the application and effect of intermittent fasting (IF) in promoting health, reducing body weight, reducing inflammation and improving metabolic health. As a dietary intervention, IF affects the metabolic and endocrine responses of the body by limiting the time of food intake. Different types of IF such as time-limited fasting (TRF), alternate day fasting (ADF) and periodic fasting (PF) are discussed, as well as their respective biological mechanisms. Emphasis was placed on the analysis of the effect of IF on reducing the level of inflammation in the body, especially its role in reducing inflammatory markers such as C-reactive protein and tumor necrosis factor-α. At the same time, the application cases of IF in fat reduction and cardiovascular health improvement were also reviewed. Although current research shows the positive effects of IF in many ways, more research is needed on its long-term effects, individual differences and safety. As a multi-faceted dietary intervention strategy, intermittent fasting's application potential in modern public health management deserves further exploration. Read More

Abstract: With the development of sports nutrition, creatine, as a sports nutrition supplement, has shown remarkable effects in improving sports performance, strengthening muscle strength and endurance. In this paper, creatine's physiological effects and the mechanism of use, side effects and safety studies, the impact on sports performance, the application in athletes and the collocation of daily nutrition intake were reviewed. Studies have shown that creatine supplements improve athletes' performance in short bursts of high-intensity exercise by increasing creatine phosphate storage in muscles. Although creatine supplements are considered safe in most cases, further research is needed on the effects of side effects and dosages. Future research is needed to explore the optimal use of creatine, its use in specific populations, and its combination and intake with other nutrients. Read More

Abstract: This article discusses the feasibility study entailing an innovative design in the manufacture of antimalarial drugs using Halofuginone and its derivatives as the active ingredients. Malaria is still a significant public health problem in the 21st century. Going beyond well-known approaches, novel treatment modalities should be studied. The research evaluates the ability of Halofuginone derivatives to stop the progression of Malaria, displaying great promise as a successful alternative for treating this disease. The experiment provides proof of the antimalarial efficacy of Halofuginone as an anti-Plasmodium (P. falciparum), finding about their possible mechanisms of action using structural research. Ideally, alterations are carried out to limit its toxicity, but the same task with posing their own challenges is maintaining a safety profile. The advantages of compounds prepared based on Halofuginone as candidates for clinical trials were considered, and collaboration and financial support were said to be potential facilitators. Overall, the study reinforces the efficacy of Halofuginone derivatives in Malaria and underscores the value of natural products in drug discovery. Read More

Abstract: As a neurodegenerative disease, early diagnosis of Alzheimer's disease (AD) is essential for delaying the progress of the disease. Due to the limitations of diagnostic methods, new biomarkers and detection technologies are urgently needed. Therefore, this paper mainly discusses the research and development of specific antibodies by lymphocyte hybridoma technology and the application of proximity extension assay (PEA) methodology in the field of in vitro diagnosis (IVD) for early screening detection of AD [1]. By applying Olink proteomic analysis technology with PEA methodology, the potential value of Olink proteomic analysis technology in improving the diagnostic accuracy and early identification of AD is clearly explained, which provided new ideas for future research direction and clinical application. Read More

Abstract: Ischemic heart disease (IHD) remains a leading cause of morbidity and mortality worldwide, significantly burdening healthcare systems. As populations age and lifestyles increasingly adopt unhealthy habits, the incidence of IHD continues to rise, prompting advancements in therapeutic interventions. According to the World Health Organization (WHO), IHD is a leading cause of death globally, accounting for millions of deaths each year. The continuous evolution of treatment modalities, from pharmacotherapy to surgical interventions, reflects the ongoing quest to enhance patient outcomes and manage the disease more effectively. Despite advancements, significant disparities exist in IHD treatment across different regions. Developed countries typically have access to advanced medical technologies and resources, offering higher standards of care. In contrast, developing nations often face challenges such as inadequate medical infrastructure and uneven healthcare quality, leading to suboptimal treatment outcomes for IHD patients. This paper aims to provide a comprehensive overview of the evolution of IHD therapeutic interventions from a global perspective, highlighting significant milestones and comparing treatment practices across various countries. By examining the application and effectiveness of different treatment methods, we seek to identify strengths and weaknesses in IHD management worldwide, offering insights for future improvements in global healthcare strategies. Read More

Abstract: As globalisation encourages migration and the blending of diverse cultures, Canadian blood donation faces new opportunities and challenges. According to Statistique Canada, “there were more than 1.7 million Chinese people residing in Canada in 2021… representing 4.7% of the total population” and we can get more detailed content on Statistics Canada, the aticle is "Chinese New Year and quality of life among Chinese in Canada". As the Chinese population, including Chinese international students, permanent residents, and Chinese Canadians, grows in Canada, how to attract this group of donors is crucial to sustaining Canada's blood reservoir. For this reason, a self-report psychological survey was spread near Vancouver, British Columbia, directed toward participants who identified themselves as ethnically Chinese, or Chinese Canadian. To understand the Chinese donor’s psychological shifts and needs experienced by them during the process of donating blood, it was found through this psychological survey that Chinese donors generally feel psychological unease before donating blood, such as unfamiliarity with the blood donation process and worries about potential side effects after donating blood. Similarly, it is recommended to enhance communication efficiency between Chinese donors, who may not speak English fluently, and the staff members by employing more multilingual staff, along with considering the recruitment of a psychological counselling team, to strengthen the current blood donation system. Implementing improvements for raising awareness and publicising blood donation, generating a comforting experience and environment for Chinese donors, and strengthening safety measures and trust in the process are also essential. All the possible suggestions are proposed in the hope of eliminating the psychological anxiety of Chinese donors, which may enhance their willingness and motivation to donate blood and increase the blood supply for Canada’s blood reserve. Read More

Abstract: This research was carried out to detect the influence of the proton pump mechanism function on the EGFR inhibitor. Human gastric cancer cell line MKN-45 cells were divided into different concentrations of EGFR inhibitors and treated with either AG1478 or PD153035. Western Blot and immunofluorescence describe the expression of proton pump (H+/K+ ATPase). Next, the phosphorylated levels of ERK and AKT were analyzed. The overall disruption and strong results in the effects of EGFR inhibition, proton-pump transcription, and phosphorylation of ERK and AKT indicated the vital importance of this pathway. Moreover, this study also indicated that EGFR inhibitors were inhibitors of the EGFR signaling pathways themselves due to a decrease in the expression and activity of the proton pump; moreover, this inhibitory effect was closely related to drug concentration. Such findings open up new treatment opportunities for various gastric diseases and underline the possibly critical role of EGFR in gastric acid regulation. Read More

Abstract: As a malignant tumor with high morbidity and mortality in the world, the treatment of non-small cell lung cancer is still facing great challenges. Although new breakthroughs have been made in recent years and great progress has been made in chemotherapy and targeted therapy, the five-year survival rate of most NSCLC patients is still at a low level. The emergence of drug resistance is one of the important factors affecting the therapeutic effect and survival rate of patients. PRMT5 (protein arginine methyltransferase 5), as a type II arginine methyltransferase, plays an important role in cancer cell proliferation, differentiation, apoptosis and tumorigenesis. At present, people pay more and more attention to the research on the mechanism of PRMT5 in tumor drug resistance. In this review, we summarize the mechanism of PRMT5 in chemotherapy resistance of non-small cell lung cancer and discuss potential strategies to avoid or overcome chemotherapy resistance. Read More

Abstract: With the spread of the concept of team medicine, active nurse-doctor collaboration is closely related to nursing quality. Nursing standards recognize that collaborative practice is a necessary condition for high-quality patient care, but many nurses are often reluctant to participate in interprofessional teams, indicating that challenges in nurse-doctor collaboration still exist. This study aimed to investigate the relationship between demographic data and nurse interprofessional satisfaction of medical and surgical nurses in tertiary hospitals in Shandong Province, and to provide a reference direction for improving teamwork. Methods: The research method was a cross-sectional study. Medical and surgical nurses in three tertiary hospitals in Shandong Province were surveyed. Medical and surgical nurses who were officially registered in the hospital and had been engaged in internal medicine or surgery for at least one year were selected. They were aged 18 to 45 years. The researchers used SPSS software to analyze the data, and descriptive statistics (frequency percentage distribution, mean score, and standard deviation) were used to present the satisfaction scores. If the data did not follow a normal distribution, nonparametric tests were used. Results: The average scores of the interprofessional collaboration satisfaction scale for the participating nurses were: "overall expectation" 2.67; "perception dimension of professional collaboration" 3.78; "The overall relationship satisfaction of professional cooperation" 3.83; "Communication and tolerance of interprofessional collaboration" 3.80; "Equality of interprofessional collaboration" 3.81; "Satisfaction with interprofessional collaboration" 2.98. The results of non-parametric tests showed that there was a significant difference between marriage and nurses' satisfaction with interprofessional collaboration (P<0.05). Conclusion: The overall satisfaction of nurses with interprofessional collaboration in three tertiary … Read More

Abstract: Hyaluronic acid, as a widely used polymer material in clinical practice, has been proven to have numerous biological functions. In dentistry, the application of hyaluronic acid also has certain advantages and can be used to treat oral diseases. However, there are still many issues that need to be explored in research. Therefore, this article aims to explore the current application status and existing problems of hyaluronic acid in periodontal disease, and further test the effectiveness and safety of hyaluronic acid in the treatment of periodontal disease, in order to propose a more reasonable and effective treatment plan for periodontal disease. Read More

Abstract: Recurrent aphthous ulcer in the oral cavity is a common oral mucosal disease with periodic, recurrent, and self-limiting characteristics. This article aims to explore the new progress of integrated traditional Chinese and Western medicine in the treatment of recurrent aphthous ulcers in the oral cavity. Through a comprehensive analysis of relevant research, the advantages and mechanisms of integrated traditional Chinese and Western medicine in improving efficacy, reducing symptoms, and reducing recurrence rates are elaborated, providing reference for clinical treatment. Read More

Abstract: Core training plays a vital role in modern athletic training and has a significant impact on an athlete's performance across a wide range of sports. The purpose of this article is to explore how core training can improve an athlete's explosive power and the specific contribution of this training method to athletic performance. Through literature review and empirical analysis, this study comprehensively evaluated the methods and effects of core muscle training and its application in different sports. The study found that systematic core muscle training significantly improved the athlete's stability, balance and power transfer efficiency, thereby enhancing their explosive power. This study provides athletes and coaches with scientific training guidance that can help them achieve better performance in competitive sports. Read More

Abstract: To address the disconnection between the educational structure of nursing teams and the rapid development of China's medical and health industry, there is a shortage of highly educated nursing personnel. In 2016, Chinese universities introduced a new training model for nursing graduate students: non-full-time nursing graduate students. Due to its late development, this model needs continuous improvement. Understanding the training experience of non-full-time nursing graduate students is crucial for refining the training model. This study explores the experiences of non-full-time nursing graduate students and provides a basis for improving their training in China. Semi-structured qualitative interviews were conducted with 20 non-full-time nursing graduate students. Data were collated and analyzed using Colaizzi's method. The analysis identified five themes related to the study experiences of non-full-time nursing graduate students: (1) maladaptation to diversified roles; (2) weak scientific research foundation; (3) lack of high-level guidance in clinical practice; (4) concern about social recognition; and (5) lack of educational and training resources. Competent government and training units should fully understand the experiences of non-full-time nursing graduate students and improve their training model from the students' perspective to promote the development of high-quality nursing talents. This will ultimately benefit employers, training units, individuals, and patients. Read More

Abstract: Hyaluronic acid, as a widely used polymer material in clinical practice, has been proven to have numerous biological functions. In dentistry, the application of hyaluronic acid also has certain advantages and can be used to treat oral diseases. However, there are still many issues that need to be explored in research. Therefore, this article aims to explore the current application status and existing problems of hyaluronic acid in pulpitis, and further test the effectiveness and safety of hyaluronic acid in the treatment of pulpitis, in order to propose a more reasonable and effective treatment plan for pulpitis. Read More

Abstract: Oral lichen planus (OLP) is a common chronic oral mucosal disease, with a complex etiology and difficult treatment. [1] This article reviews the new progress of integrated traditional Chinese and Western medicine treatment for oral lichen planus, including Western medicine treatment methods, traditional Chinese medicine treatment concepts, specific plans for integrated traditional Chinese and Western medicine treatment, as well as their advantages and mechanisms of action. It also looks forward to future research directions. Read More

Abstract: This study proposed initial stage SEI1I2I3RD and final stage SEQ I1I2I3RD models to deeply analyze the transmission dynamics of COVID-19 at different stages and propose scientific prevention and control strategies. The initial stage SE I1I2I3RD model divides infected individuals into mild, moderate, and severe cases during the early stage of the epidemic, effectively predicting the number of new infections and cumulative recoveries. The final stage SEQ I1I2I3RD model builds on the initial stage SE I1I2I3RD model by adding a quarantine compartment, which reflects the impact of nucleic acid testing and quarantine measures on epidemic control. By introducing dynamic parameters and nonlinear processing, the final stage SEQ I1I2I3RD model significantly improves prediction accuracy. The study demonstrates that increasing the isolation rate, reducing the daily contact rate of infected persons, and improving the recovery rate of mildly infected persons are effective control strategies. Based on the model's predictions, policy recommendations such as enhancing public health education, strictly implementing isolation measures, restricting population movement, and optimizing medical resource allocation are proposed to effectively control the spread of the epidemic, reduce the burden on the healthcare system, and create favorable conditions for economic recovery. Read More