Abstract: Driven by the dual strategies of national fitness and building a sports - power country, the half - marathon sport is developing in a large - scale and professional manner. The group of popular elite half - marathon runners is constantly growing. However, this group generally faces problems such as good aerobic capacity but insufficient lower - limb strength and speed ability, fragmented training time, and a high risk of injury from high - intensity strength training. Blood flow restriction combined with low - intensity resistance training (LL - BFRT), characterized by "low load, high neuromuscular adaptation", can enhance muscle strength without the need for professional equipment, providing a new approach to address the training pain points of popular elite half - marathon runners. This paper reviews the mechanism of action of LL - BFRT, its research status at home and abroad, analyzes the theoretical basis and practical adaptability of LL - BFRT for this group in combination with the specific characteristics of the half - marathon sport, explores the key points of its application scheme design, and finally points out the current research deficiencies and future directions. The aim is to provide a theoretical reference for the application of LL - BFRT in half - marathon training. Read More

Abstract: This article takes one of the technical cores - regulatory mechanisms - as the starting point to discuss the direct risks such as off target and chimerism caused by the failure or imperfection of regulatory mechanisms; And analyze the potential medical risks, gene pool changes, ethical risks, and social evolution risks that this technology may bring from the perspectives of personal level, reproductive genetics, ethical and social aspects, and ecological evolution. This article also attempts to propose specific and feasible risk prevention and regulatory measures from the perspectives of technology, evaluation standards, laws and regulations, and social supervision, in order to benefit the cautious and rational use of embryo gene editing technology. Read More

Abstract: Natural tannins, as polyphenolic compounds widely present in plants, have garnered increasing attention due to their diverse biological activities and industrial applications. This paper systematically examines the current research landscape surrounding natural tannin extraction. Plants such as gallnuts, tea leaves, and tree barks serve as primary sources, with tannins classified into hydrolysable and condensed types based on their chemical structures. Various extraction techniques including solvent extraction, ultrasound-assisted extraction, and enzymatic methods have been developed, each demonstrating distinct advantages in terms of efficiency and environmental impact. Process optimization through parameter adjustment has shown significant improvements in yield and purity. Recent advancements highlight the potential of green extraction technologies that minimize chemical usage while maintaining extraction performance. The extracted tannins exhibit promising applications in leather production, food preservation, and pharmaceutical formulations due to their antioxidant and antimicrobial properties. Future research directions should focus on developing cost-effective large-scale extraction methods and exploring novel applications in emerging fields. Continuous innovation in extraction technologies coupled with sustainable sourcing strategies will be crucial for meeting the growing industrial demand while addressing environmental concerns. Read More

Abstract: Achieving universal health coverage (UHC) is one of the core goals of the Sustainable Development Goals (SDGs), which aim to ensure that all individuals have access to quality health care without facing financial hardship. As the largest developing country, China has made remarkable progress in achieving UHC through healthcare financing and government leadership. However, urban and rural areas in China still face challenges in terms of access to health care, quality, and resource allocation. This structured literature review of articles published between 2010 and 2025 was conducted through PubMed and Google Scholar, and a total of 31 studies related to UHC and health systems in China were included as evidence for analysis. Through this literature review, we found that China has achieved more than 95% population coverage in terms of UHC, significantly improving access to basic health services. However, China's financial protection indicators, such as Catastrophic Health Expenditure (CHE), are still higher than those of comparable countries. There are significant differences in the distribution of health human resources, the quality of medical services, and the quality of facilities between urban and rural medical institutions in China. Read More

Abstract: Adenosine diphosphate ribose polymerase (PARP) inhibitors have become an important targeted therapy for ovarian cancer patients carrying homologous recombination repair defects (HRD), but acquired resistance severely limits the long-term benefits of PARP inhibitors. Recent studies have shown that epigenetic remodeling mediated by DNA methylation plays an important role in the resistance process of PARP inhibitors. Therefore, in addition to inducing HRD phenotype reversal by silencing homologous recombination repair related genes, it can also synergistically mediate drug resistance by regulating the tumor immune microenvironment. This article reviews the epigenetic reversal of HRD and its impact on the immune microenvironment in ovarian cancer PARPi acquired resistance through DNA methylation. This article further introduces the application prospects, existing problems, and future prospects of demethylation drugs combined with PARP inhibitors or immunotherapy for DNA methylation, providing a new theoretical basis and possible approaches for solving clinical drug resistance. Read More

Abstract: Glioma is the most common type of primary intracranial malignant tumor; The highly heterogeneous and aggressive characteristics pose great challenges to the diagnosis and treatment of patients. Accurate preoperative grading, molecular typing prediction, and personalized treatment are of great significance in improving patient survival time and prognosis. With the development of multimodal magnetic resonance imaging technology, it can reflect the pathological and physiological characteristics of tumors from multiple angles and in all directions, including changes in morphology, function, and metabolism. At the same time, with the development of artificial intelligence, especially machine learning and deep learning, powerful technical means have been provided for mining deep level information from image big data and establishing objective quantitative analysis models. This article introduces the methods of using various MRI data for characteristic analysis of gliomas, and presents the process of constructing an artificial intelligence assisted diagnostic model, including image data preprocessing, tumor segmentation, feature extraction and screening, grading diagnosis, and molecular typing prediction model design and validation. Finally, the support of artificial intelligence assisted decision support systems for clinical diagnosis and treatment was discussed, including preoperative planning, prognosis assessment, efficacy evaluation, and AI visualization assisted decision support in multidisciplinary consultations; The combination of multimodal imaging and artificial intelligence is expected to promote the transformation of glioma from imaging diagnosis to diagnosis and treatment decision-making, and promote the development of its grading diagnosis and treatment model. Read More

Abstract: Parkinson's disease (PD) is a neurodegenerative disease that seriously threatens human health in contemporary society [1]. Sense of Coherence (SOC) is a concept in positive psychology. By reviewing the SOC of PD patients, this paper elaborates on the current status of SOC in PD patients based on positive psychology theory, explores the influencing factors of SOC in PD patients, and clarifies the important significance of improving the SOC level of PD patients. The study aims to enhance the SOC level of PD patients, improve their quality of life, and provide a theoretical basis for effective clinical interventions. Read More

Abstract: In the context of the rapid development of precision medicine, precision surgery has gradually become the core development direction of modern surgery, which emphasizes accurate diagnosis, precise localization, minimally invasive operation, real-time monitoring and individualized treatment. With the unique advantages of real-time imaging, non-invasiveness, repeatability, bedside availability and dynamic visualization, ultrasound is highly consistent with the educational needs and practical scenarios of precision surgery. However, traditional surgical teaching is still restricted by static anatomical teaching, insufficient clinical practice opportunities, single teaching mode and lack of interdisciplinary integration, which makes it difficult to systematically cultivate students’ precision thinking, spatial cognitive ability and standardized surgical operation ability. Based on the core connotation and development trend of precision surgery, this paper analyzes the realistic dilemmas and deep-seated problems existing in traditional surgical teaching, and systematically expounds the specific application paths and multi-dimensional application values of ultrasound medicine in surgical teaching from four aspects: visualized anatomical teaching, standardized skill training, interdisciplinary knowledge integration and diversified teaching evaluation. This study confirms that the deep integration of ultrasound medicine into the whole process of surgical teaching can effectively break through the limitations of traditional teaching, significantly improve the intuitiveness, scientificity and effectiveness of surgical teaching, enhance students’ three-dimensional spatial cognition and clinical practical ability, cultivate rigorous precision thinking and interdisciplinary comprehensive competence, and provide a practical and feasible path for medical colleges and universities to cultivate high-quality surgical talents adapting to the development requirements of modern … Read More

Abstract: The increasing demand for sustainable energy storage solutions has driven research into eco-friendly materials, with coffee biomass emerging as a promising candidate due to its natural abundance and renewable characteristics. This review systematically examines the fundamental properties of coffee biomass-derived materials, highlighting their unique structural and chemical features that contribute to enhanced electrochemical performance. The application of these materials in capacitors demonstrates significant improvements in capacitance and cycling stability, attributed to their porous architecture and favorable surface chemistry. Furthermore, the integration of coffee-based components in energy storage devices showcases notable advancements in efficiency and environmental compatibility. The findings underscore the potential of coffee biomass as a viable alternative to conventional materials, offering both economic and ecological benefits. Future research directions emphasize the optimization of processing techniques and the exploration of hybrid systems to further elevate performance metrics, paving the way for broader implementation in next-generation energy technologies. Read More

Abstract: Music therapy is a promising adjunct to depression care, yet effects likely vary with everyday listening. In a cross-sectional online survey (N = 736), we examined associations between preferred genres, self-reported typical tempo (beats per minute; BPM), and engagement mode (composing/playing/exploring vs. purely receptive) with single-item anxiety and depression (0–10). After prespecified cleaning (e.g., implausible BPM < 30 or > 300 excluded) and listwise analysis, we estimated OLS models with HC3 standard errors; genre differences used one-way ANOVA (inference restricted to adequately sized groups), reporting ω² and 95% CIs. Typical BPM showed small, positive linear associations with both anxiety and depression; the quadratic term was null and model R² values were modest. Genre effects were small at the omnibus level, and only a limited subset of pairwise contrasts remained significant after correction (e.g., Metal vs. Classical/R&B; Video-game music vs. Classical for anxiety). Active engagement showed selective, small associations (composition with lower depression) that warrant experimental tests. Findings, derived from a non-clinical, correlational dataset, argue for individualised use of music in practice and for prospective trials that manipulate engagement type and tempo within genres. Read More

Abstract: To evaluate the impact of China's 2009 maternal health management program on service utilization and child health, and examine their association. Using 1998-2020 national time-series data, interrupted time series regression analyzed changes in four maternal service indicators and four child mortality indicators post-implementation. Pearson correlation assessed service-mortality associations. All maternal services showed significant immediate increases post-2009 (systematic management: B=5.53, p<0.01) and accelerated long-term trends (p<0.05). Child mortality continued pre-existing declines; perinatal mortality decreased immediately (B=-0.665, p<0.05). All service indicators correlated strongly and negatively with all mortality indicators (|r|>0.74, p<0.01).The 2009 program sustainably improved maternal service utilization and reinforced declining child mortality trends. Strong negative correlations confirm comprehensive maternal healthcare's critical role in improving child survival. Read More

Abstract: Simao pine is a dominant native tree species in Puer, Yunnan, China, with abundant underutilized pine needle resources. This study optimized the ultrasonic-assisted extraction of total flavonoids from Simao pine needles, and evaluated the in vitro antioxidant activity of the extracts. Single-factor experiments and orthogonal test showed that the optimal extraction conditions were solid-liquid ratio 1:20, extraction temperature 80℃, and extraction time 40 min, with a maximum total flavonoid yield of 6.86%. The total phenolic content of the extract was 10.97 μg per mg of dry extract. Antioxidant assays confirmed that the extract had a DPPH radical scavenging rate over 80% at 0.6–0.8 mg/mL, and a maximum hydroxyl radical (•OH) scavenging rate of 72.29% at 0.8 mg/mL. The reducing power of the extract was significantly higher than that of vitamin C (Vc) and vitamin E (Ve) at 0.6–1.0 mg/mL. This study provides a theoretical basis for the development of Simao pine needles as a natural antioxidant resource. Read More