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Research Status and Development Prospects of Osteocyte Microenvironment Regulating Bone Regeneration After Fracture

Yuye Zhu
Vol.6, No.8, pp.18-23, 2026 DOI: 10.62051/ijphmr.v6n8.02 September 29, 2026
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Abstract: Osteocytes, the most prolific and longest lived resident cell population embedded in the mineralised skeletal matrix, have evolved from putative passive placeholders to active conductors of skeletal metabolism and regeneration. After bone fracture, the local osteocyte microenvironment, comprising the complex lacuno-canalicular fluid network, pericellular matrix, mechanical stress distribution, metabolic gradients and inflammatory signalling, is radically remodelled, in space and time. This research summarises the available data for the structural and functional mechanisms by which the osteocyte microenvironment may influence bone healing following fracture. We address the function of osteocytes in the translation of physical and chemical stimuli into particular bone repair, integrating classical concepts of mechanotransduction, apoptotic cascades of osteocytes, vascular-osteogenic link and immune-inflammatory control. Moreover, this paper highlights recent experimental and technological approaches developed to mimic or modulate the osteocyte niche, including mechanobiological stimulation, microfluidic platforms, and biomimetic scaffolds. Finally, we discuss in depth the significant translational restrictions and planned research paths in targeted treatments and multi-cellular regenerative systems.
Keywords: Osteocyte microenvironment, Bone fracture, Bone regeneration, Mechanotransduction, Lacuno-canalicular network, Targeted bone remodeling
APA Citation: Yuye Zhu (2026). Research Status and Development Prospects of Osteocyte Microenvironment Regulating Bone Regeneration After Fracture. International Journal of Public Health and Medical Research, 6(8), 18-23. https://doi.org/10.62051/ijphmr.v6n8.02

References

  1. Burger, E. H., & Klein-Nulend, J. (1999). Mechanotransduction in bone—role of the lacunocanalicular network. The FASEB Journal, 13(Suppl 1), S101–S112. [https://doi.org/10.1096/fasebj.13.9001.s101]
  2. Robling, A. G., Castillo, A. B., & Turner, C. H. (2006). Biomechanical and molecular regulation of bone remodeling. Annual Review of Biomedical Engineering, 8, 455–498. [https://doi.org/10.1146/annurev.bioeng.8.061505.095721]
  3. Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., Ito, M., Takeshita, S., & Ikeda, K. (2007). Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metabolism, 5(6), 464–475. [https://doi.org/10.1016/j.cmet.2007.05.001]
  4. Bonewald, L. F. (2011). The amazing osteocyte. Journal of Bone and Mineral Research, 26(2), 229–238. [https://doi.org/10.1002/jbmr.320]
  5. Qin, L., Liu, W., Cao, H., & Xiao, G. (2020). Molecular mechanosensors in osteocytes. Bone Research, 8, 23. [https://doi.org/10.1038/s41413-020-0099-y]
  6. Claes, L., Recknagel, S., & Ignatius, A. (2012). Fracture healing under healthy and inflammatory conditions. Nature Reviews Rheumatology, 8(3), 133–143. [https://doi.org/10.1038/nrrheum.2012.1]
  7. Kennedy, O. D., Herman, B. C., Laudier, D. M., Majeska, R. J., Sun, H. B., & Schaffler, M. B. (2012). Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone, 50(5), 1115–1122. [https://doi.org/10.1016/j.bone.2012.01.025]
  8. Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013). The osteocyte: An endocrine cell... and more. Endocrine Reviews, 34(5), 658–690. [https://doi.org/10.1210/er.2012-1026]
  9. Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014). Osteocytes: Master orchestrators of bone. Calcified Tissue International, 94(1), 5–24. [https://doi.org/10.1007/s00223-013-9790-y]
  10. Loi, F., Córdova, L. A., Pajarinen, J., Lin, T. H., Yao, Z., & Goodman, S. B. (2016). Inflammation, fracture and bone repair. Bone, 86, 119–130. [https://doi.org/10.1016/j.bone.2016.02.020]
  11. Bolamperti, S., Villa, I., & Rubinacci, A. (2022). Bone remodeling: An operational process ensuring survival and bone mechanical competence. Bone Research, 10, 48. [https://doi.org/10.1038/s41413-022-00219-8]
  12. Bhandari, M., Schemitsch, E. H., Karachalios, T., Sancheti, P., Poolman, R. W., Caminis, J., Daizadeh, N., Dent-Acosta, R. E., Egbuna, O., Chines, A., & Miclau, T. (2020). Romosozumab in skeletally mature adults with a fresh unilateral tibial diaphyseal fracture: A randomized phase-2 study. Journal of Bone and Joint Surgery, 102(16), 1416–1426. [https://doi.org/10.2106/jbjs.19.01008]