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Multifunctional Acoustic Nanoplatforms based on Sonodynamic Therapy for Solid Tumor: A review

Bo Ren, CharngChoon Wong
Vol.6, No.8, pp.1-17, 2026 DOI: 10.62051/ijphmr.v6n8.01 September 29, 2026
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Abstract: The main clinical treatment options for solid tumor include surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, these treatments all have limitations. Surgery is generally not feasible for the majority of patients with advanced or metastatic disease, whereas chemotherapy, owing to its limited targeting specificity, is frequently accompanied by severe systemic toxicity. In addition, targeted therapy and immunotherapy are only beneficial for selected subsets of patients. Therefore, there is a compelling need for combination strategies to overcome these challenges. As an emerging non-invasive modality for cancer treatment, sonodynamic therapy (SDT) mainly exploits sonosensitizer-nanoparticle conjugates (SNCs) to generate abundant reactive oxygen species (ROS) under ultrasound (US) irradiation, thereby inducing apoptosis of malignant tumor cells. SDT has the advantages of noninvasiveness, geographic targeting, deep penetration, and minimal side effects. The SNCs in this review refer to multifunctional nanoplatforms loaded with sonosensitizers and therapeutic antitumor agents, combining SDT with other modalities. This review focuses on the critical components of SNCs and recent developments in SNCs-assisted SDT in anticancer therapy, elaborates on the potential mechanisms of SDT, as well as the related outcomes. Moreover, this review highlights the promising benefits of synergistic treatment achieved by combining SDT with other therapeutic strategies. Despite the promising potential of SDT in cancer medicine, this review acknowledges the challenges of this strategy and proposes a positive direction for SNC-assisted SDT in anticancer medicine.
Keywords: Sonosensitizer, Sonodynamic therapy, Low-intensity focused ultrasound, Cavitation, Reactive oxygen species
APA Citation: Bo Ren, CharngChoon Wong (2026). Multifunctional Acoustic Nanoplatforms based on Sonodynamic Therapy for Solid Tumor: A review. International Journal of Public Health and Medical Research, 6(8), 1-17. https://doi.org/10.62051/ijphmr.v6n8.01

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