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An Analysis on the Application of In‑vitro Experimental Fluid Circulation Loop in the Evaluation of Cardiac and Cerebral Circulation Medical Devices

Yilin Du
Vol.6, No.8, pp.36-43, 2026 DOI: 10.62051/ijphmr.v6n8.05 September 29, 2026
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Abstract: Conventional medical-device evaluation often involves animal experiments and clinical investigations, both of which require substantial time and resources and are subject to ethical and practical constraints. Both require significant investment and a long period of time, have numerous ethical constraints, and once the testing plan is set, it is difficult to make changes. It is even more challenging to conduct innovative tests. With the acceleration of device updates, this verification model has become increasingly strained. Cardiovascular and cerebrovascular diseases impose a substantial clinical burden, and the performance of related medical devices directly affects treatment outcomes and postoperative recovery. The pressure on public health prevention and control is constantly increasing. At the clinical level, the performance of cardiovascular and cerebrovascular devices directly affects the treatment outcome and postoperative recovery quality of critically ill patients, and they are indispensable equipment in intensive care. The introduction of the extracorporeal circulation circuit system has opened up a new way for verification work. This system can simulate the real hemodynamic conditions of the human cardiovascular system, and the experimental parameters can be adjusted as needed, precisely compensating for the shortcomings of traditional methods. This article focuses on the engineering implementation and application of this platform. Based on experimental records and long-term practical experience, the author explains the hardware composition, operating characteristics, and simulation accuracy of the system, and combines detection examples of interventional and circulatory support devices to examine their actual test results. During the experiment, some problems have also been gradually exposed: there is still a deviation between physiological simulation and the real environment, the performance stability of the supporting consumables is poor, and the industry test standards have not yet been unified. These aspects constitute the key topics of discussion in this article. The above research results provide a basis for the structural optimization, parameter calibration, and standard formulation of the extracorporeal evaluation system, and have direct reference significance for the preclinical verification of similar medical devices.
Keywords: Extracorporeal fluid circulation circuit, Cardiovascular and cerebral circulation, Medical apparatus and instruments, Haemodynamics, Separate assessment
APA Citation: Yilin Du (2026). An Analysis on the Application of In‑vitro Experimental Fluid Circulation Loop in the Evaluation of Cardiac and Cerebral Circulation Medical Devices. International Journal of Public Health and Medical Research, 6(8), 36-43. https://doi.org/10.62051/ijphmr.v6n8.05

References

  1. Li, H., Hong, W., Yu, H., et al. (2025). Technological evolution of in vitro mock circulatory loops for advanced cardiovascular assist device evaluation. Frontiers in Physiology, 16, 1610040.
  2. Xu, K. W., Gao, Q., Wan, M., et al. (2023). Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies. Frontiers in Physiology, 14, 1175919.
  3. Rocchi, M., Ingram, M., Claus, P., et al. (2023). Use of 3D anatomical models in mock circulatory loops for cardiac medical device testing. Artificial Organs, 47(2), 260–272.
  4. Girdhar, G., Ubl, S., Jahanbekam, R., et al. (2019). Thrombogenicity assessment of Pipeline, Pipeline Shield, Derivo and P64 flow diverters in an in vitro pulsatile flow human blood loop model. eNeurologicalSci, 14, 77–84.
  5. Hong, W., Yu, H., Chen, J., et al. (2023). A mock circulation loop to characterize in vitro hemodynamics in human systemic arteries with stenosis. Fluids, 8(7), 198.
  6. Packy, A., D’Souza, G. A., Farahmand, M., et al. (2022). Simulating radial pressure waveforms with a mock circulatory flow loop to characterize hemodynamic monitoring systems. Cardiovascular Engineering and Technology, 13(2), 279–290.
  7. Horvath, D. J., Gao, S., Fukamachi, K., et al. (2020). Development of a circulatory mock loop for biventricular device testing with various heart conditions. The International Journal of Artificial Organs, 43(9), 600–605.
  8. Cuenca‑Navalon, E., Finocchiaro, T., Laumen, M., et al. (2014). Design and evaluation of a hybrid mock circulatory loop for total artificial heart testing. The International Journal of Artificial Organs, 37(1), 71–80.
  9. Patel, M., Jamiolkowski, M. A., Vejendla, A., et al. (2023). Effect of temperature on thrombogenicity testing of biomaterials in an in vitro dynamic flow loop system. ASAIO Journal, 69(6), 576–582.
  10. van der Kolk, N. W., Rutten, M. C. M., van de Vosse, F. N. (2019). An in‑vitro flow study using an artificial circle of willis model for validation of an existing one‑dimensional numerical model. Annals of Biomedical Engineering, 47(4), 1092–1104.
  11. Wang, Y., Zhang, Y., Liu, Y., et al. (2021). A mock circulation loop for in vitro hemodynamic evaluation of aorta: application in aortic dissection. Journal of Endovascular Therapy, 28(6), 912–923.
  12. Poulos, D. A., Fregona, V., Luraghi, G., et al. (2024). Investigation of stent retriever removal forces in an in vitro middle cerebral artery model. Frontiers in Neurology, 15, 1486738.
  13. Bono, N., Sironi, S., Casari, S., et al. (2024). An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs. Artificial Organs, 48(4), 336–346.
  14. Siljander, A., Toth, J., Marte, J., et al. (2025). An in vitro assessment of aspiration technologies: location of conduit for 6F aspiration catheters and design of catheter tip influence clot retrieval success. Interventional Neuroradiology.
  15. Jamiolkowski, M. A., Patel, M., Golding, M. D., et al. (2022). Comparison of animal and human blood for in vitro dynamic thrombogenicity testing of biomaterials. Artificial Organs, 46(12), 2400–2411.