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Exploration on the Influence of Oxidative Stress on the Progression of Age-related Degenerative Lesions

Yiwen Wang
Vol.6, No.7, pp.63-68, 2026 DOI: 10.62051/ijphmr.v6n7.09 August 28, 2026
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Abstract: Research on how oxidative stress affects the development of age-related degenerative diseases. Rather than considering oxidative stress as an increase in free radicals, this paper now refers to it as a fluctuating disorder in redox homeostasis that involves reactive oxygen species, antioxidant defence, mitochondrial function, inflammatory amplification and damaged cell repair. Based on the classic theories of ageing and later review literature, this paper examines how oxidative stress contributes to the accumulation of molecular damage and promotes structural and functional deterioration in ageing tissues. Oxidative stress is also related to disease, and at the same time, it is a type of damage that occurs in blood vessels, nerves and metabolism. Therefore, it has been proposed that the development of degenerative changes in old age is the result of multiple interconnected redox, inflammatory and signalling pathways rather than single-cause damage to tissues.
Keywords: Oxidative stress, Aging, Degenerative lesions, Reactive oxygen species, Redox homeostasis, Age-related disease
APA Citation: Yiwen Wang (2026). Exploration on the Influence of Oxidative Stress on the Progression of Age-related Degenerative Lesions. International Journal of Public Health and Medical Research, 6(7), 63-68. https://doi.org/10.62051/ijphmr.v6n7.09

References

  1. Harman, D. (1956). Aging: A theory based on free radical and radiation chemistry. Journal of Gerontology, 11(3), 298 300.
  2. Harman, D. (1992). Free radical theory of aging. Mutation Research/DNAging, 275(3 6), 257 266.
  3. Finkel, T., & Holbrook, N. J. (2000). Oxidants, oxidative stress and the biology of ageing. Nature, 408(6809), 239 247.
  4. Finkel, T. (2003). Oxidant signals and oxidative stress. Current Opinion in Cell Biology, 15(2), 247 254.
  5. Betteridge, D. J. (2000). What is oxidative stress?. Metabolism, 49(2, Suppl. 1), 3 8.
  6. Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757 772.
  7. Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology, 39(1), 44 84.
  8. Halliwell, B. (2007). Biochemistry of oxidative stress. Biochemical Society Transactions, 35(5), 1147 1150.
  9. Uttara, B., Singh, A. V., Zamboni, P., & Mahajan, R. T. (2009). Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options. Current Neuropharmacology, 7(1), 65 74.
  10. Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005). Oxidative stress and vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(1), 29 38.
  11. Płóciniczak, A., Bukowska Olech, E., & Wysocka, E. (2025). The complexity of oxidative stress in human age related diseases—A review. Metabolites, 15(7), 479.